Inflammatory markers are elevated in early pregnancy, but not late pregnancy, in women with overweight and obesity that later develop preeclampsia

Abstract Problem Obesity and preeclampsia both involve a pathological inflammatory response, which may be how obesity increases risk. Previous studies have failed to assess robust measurements of markers across gestation, specifically in overweight/ obese women the context preeclampsia. Method study We measured 20 plasma via multiplex assay (ThermoFisher Inflammation plex Human ProcartaPlex Panel) three trimesters pregnancy an existing cohort overweight who developed ( n = 37) without 74). Mann–Whitney U tests examined differences marker concentrations between cases controls. Repeated measures ANOVA were used explore over time within Results Pro‐inflammatory (IL‐1α, IL‐1β, IL‐6, IFN‐α, IFN‐γ, GM‐CSF, IL‐12p70, IL‐17α, TNF‐α, IL‐8) anti‐inflammatory (IL‐4, IL‐10, IL‐13) higher first second trimester participants later compared those did not p < .05). Only TNF‐α IL‐8 remained elevated third trimester. Inflammatory change but increase Conclusion Our findings diverge from prior studies, predominantly non‐obese women, that report lower circulating cytokines versus normotensive pregnancy, particularly by late pregnancy. posit with develop entered heightened pro‐inflammatory state likely related obesity, increased risk for Further are needed investigate if maker profiles differ women.